ea0060oc3 | (1) | UKINETS2018
Berner Alison M
, Pipinikas Christodoulos
, Karpathakis Anna
, Dibra Harpreet K
, Moghul Ismail
, Webster Amy
, Luong Tu Vinh
, Thirlwell Christina
Neuroendocrine tumours (NETs) of unknown primary (UP-NETs) represent up to 22% of NETs. Primary site identification enables patients to access appropriate treatment but is not always possible by immunohistochemistry or imaging. Given the epigenetic dysregulation of NETs, we aimed to use methylation array data to determine UP-NET tissue-of-origin. DNA from formalin-fixed paraffin embedded tissue from 76 pancreatic NET (PanNETs) (54 training and 22 validation samples) and 53 sma...